The main objective of this review is to discuss recent advancements in the overall investigation and in vivo prediction of drug absorption.The intestinal permeability of an orally administered drug (given the value Peff) has been widely used to determine the rate and extent of the drug’s intestinal absorption (Fabs) in humans.Preclinical gast
The article analyzes the concept of the Russian world, which became firmly established in the modern Russian political lexicon in the second half of the 2000s.The objective basis for the concept is the existence of numerous Russianspeaking communities outside of modern Russia, together with significant civilizational role of Russian language and cu
Abstract Background Colchicine is a clinical medicine used for relief from gout and familial Mediterranean fever.Because of its toxic effects, intravenous injection of colchicine has been banned, but it is still widely administered orally.We assayed the toxic effects of colchicine in cultured primary chorionic villus cells and amniotic fluid cells
This article identifies the socio-emotional competencies of school counsellors working with children and adolescents.The aim is to address problems related to mental health and conflict and to 159 implement training programmes.The study sample was composed of 149 counsellors working in schools.The instruments used were the CCPES-II (questionnaire o
Object detection based on wood defects involves using bounding boxes to label defects in the surface image of the wood.This step is crucial before the transformation of wood products.Due Shooting Seats to the small size and diverse shape of wood defects, most previous object detection models are unable to filter out critical features effectively.Co